I'm expecting that there's no need for an internal frame, if you want compensation or even springing there are alternatives out there. Wayoh with their brass and whitemetal bogies would seem an obvious choice, but I guess anything goes - even the Easybuild plastic ones would probably be strong enough.
The way round the need for a (bulky, visible, not prototypical) inside frame is to use Slaters 7317 or 7318 'Journal converters' with a set of B7837 3'1" disc wheels. The journal converters are used instead of the provided axle-end fixing screws and allow the use of Slater's outside bearings - as you'd find in a carriage or wagon. The result will be your wheels supported prototypically in the outside frame of the bogie, with the gearbox suspended on the axle.
I suppose the most conventional way to set up the drive would be straight down the centre of the vehicle. The red lines on the drawing show the positions of the torque-reaction arms, running from the gearbox side to the opposite end beam on the bogie frame:
The only problem (although actually a small one) is that the drive shaft passes straight underneath where you might want to put a bogie fixing screw. A solution to this would be to use a popper stud.
There are some interesting things happen if the shaft doesn't go down the centre of the bogie, one arrangement is shown here, which maintains good clearance around the bogie centre:
Your thoughts, gentlemen, please!
Steph